home.md

+## What is LocScale?
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+    
+LocScale is a reference-based local amplitude scaling tool that used prior model information to improve contrast of cryo-EM density maps.  
+The LocScale methods 
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+<img src="https://git.embl.de/jakobi/LocScale/raw/master/doc/img/EM_cyle_DM_1.jpg" width="400">
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+
 [__LocRes__](LocRes)   - local resolution estimation based on windowed FSC calculation
 
 [__LocScale__](LocScale) - local sharpening based on reference-based amplitude scaling