LocScale is a reference-based local amplitude scaling tool that used prior model information to improve contrast of cryo-EM density maps.
To reliably reflect the required level of local sharpening and local resolution variation in the target map, the model used for scaling should have refined B-factors using appropriate protocols.
To reliably reflect the required level of local sharpening and local resolution variation in the target map, the model used for scaling should have refined B-factors using appropriate protocols. The method is described in detail in a [bioRxiv](https://doi.org/10.1101/121913) preprint [1].
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The method is described in detail in a [BioRxiv](https://doi.org/10.1101/121913) preprint.
#### [__LocRes__](LocRes) - local resolution estimation based on windowed FSC calculation
#### [__LocScale__](LocScale) - local sharpening based on reference-based amplitude scaling
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#### The program is available here for [Download ](https://git.embl.de/jakobi/LocScale/tree/master/download).
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[//]:#([__LocFSC__](LocFSC) - local model validation based on FSC<sub>ref</sub> calculations)
[[1]](https://doi.org/10.1101/121913) Jakobi et al. bioRxiv 121913 (2017)
